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Abstract Objective: Most cardiac myosin binding protein C (cMyBP-C) gene mutations causing familial hypertrophic cardiomyopathy (FHC) result in C-terminal truncated proteins. By using an ...

Cardiovascular Research, Sarikas, Antonio, Carrier, Lucie, Schenke, Carolus, Doll, Daniela, Flavigny, Jeanne, Lindenberg, Katrin S., Eschenhagen, Thomas, Zolk, Oliver

Date : 01/04/2005 Item size : 316911 bytes

[...]recent studies questioned the principal capacity of circulating adult stem cells to give rise to cardiac myocytes and support myocardial regeneration [79]. In the current issue of ...

Cardiovascular Research, Zimmermann, Wolfram-Hubertus, Eschenhagen, Thomas

Date : 01/12/2005

Abstract Cardiac muscle engineering aims at providing functional myocardium to repair diseased hearts and model cardiac development, physiology, and disease in vitro. Independent of the scientific ...

Cardiovascular Research, Zimmermann, Wolfram-Hubertus, Didié, Michael, Döker, Stephan, Melnychenko, Ivan, Naito, Hiroshi, Rogge, Christina, Tiburcy, Malte, Eschenhagen, Thomas

Date : 01/08/2006 Item size : 445652 bytes

[...]the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models. Introduction The prevalence of ...

Cardiovascular Research, Wittköpper, Katrin, Dobrev, Dobromir, Eschenhagen, Thomas, El-Armouche, Ali

Date : 01/08/2011 Item size : 429005 bytes

Recent findings indicate increased late Na+ current density in human HCM cardiomyocytes. Since ranolazine has the potential to decrease myofilament Ca2+ sensitivity and late Na+ current, we ...

Cardiovascular Research, Flenner, Frederik, Friedrich, Felix W., Ungeheuer, Nele, Christ, Torsten, Geertz, Birgit, Reischmann, Silke, Wagner, Stefan, Stathopoulou, Konstantina, Söhren, ...

Date : 01/01/2016

The central assumption underlying the concept of modelling cardiomyopathies in vitro is that the phenotype seen in patients has its correlate in the pathology of isolated cardiac myocyte or heart ...

Cardiovascular Research, Eschenhagen, Thomas, Mummery, Christine, Knollmann, Bjorn C.

Date : 01/04/2015

Abstract Objective: The cardiac ankyrin repeat protein (CARP), a nuclear transcription co-factor that negatively regulates cardiac gene expression, is increased in human heart failure and in animal ...

Cardiovascular Research, Zolk, Oliver, Marx, Michael, Jäckel, Elmar, El-Armouche, Ali, Eschenhagen, Thomas

Date : 01/09/2003

Abstract Objective: The mitogen-activated kinase kinases (MEK)-extracellular signal-regulated kinases (ERK) signaling pathway is activated by agonists like catecholamines or endothelin-1 (ET-1) and ...

Cardiovascular Research, Münzel, Felix, Mühlhäuser, Ulrike, Zimmermann, Wolfram-Hubertus, Didié, Michael, Schneiderbanger, Karin, Schubert, Pia, Engmann, Sven, Eschenhagen, Thomas, Zolk, ...

Date : 01/12/2005 Item size : 304301 bytes

Conclusions: The results suggest that the reduction in I-1 protein and phosphorylation in failing human hearts leads to increased phosphatase activity which in turn may result in reduced ...

Cardiovascular Research, El-Armouche, Ali, Pamminger, Torsten, Ditz, Diana, Zolk, Oliver, Eschenhagen, Thomas

Date : 01/01/2004

[...]truncated mutants were not detected in myocardial tissue of FHC patients and were rapidly degraded by the ubiquitin-proteasome system (UPS) after gene transfer in cardiac myocytes. Since the ...

Cardiovascular Research, Mearini, Giulia, Gedicke, Christina, Schlossarek, Saskia, Witt, Christian C., Krämer, Elisabeth, Cao, Peirang, Gomes, Marcelo D., Lecker, Stewart H., Labeit, Siegfried, ...

Date : 15/01/2010