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Ehjcardiovascrec

[...]in vivo, the ratio between external work (EW) and myocardial oxygen consumption (MVO2) to obtain myocardial external efficiency (MEE) was determined in 28 pre-hypertrophic mutation carriers (14 ...

Cardiovascular Research, Witjas-Paalberends, E. Rosalie, Güçlü, Ahmet, Germans, Tjeerd, Knaapen, Paul, Harms, Hendrik J, Vermeer, Alexa M.C., Christiaans, Imke, Wilde, Arthur A.M., Dos ...

Date : 15/07/2014
Ehjcardiovascrec

Citation Michiel Helmes, Aref Najafi, Bradley M. Palmer, Ernst Breel, Niek Rijnveld, Davide Iannuzzi, Jolanda van der Velden; Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and ...

Cardiovascular Research, Helmes, Michiel, Najafi, Aref, Palmer, Bradley M., Breel, Ernst, Rijnveld, Niek, Iannuzzi, Davide, van der Velden, Jolanda

Date : 01/07/2016
Ehjcardiovascrec

Abstract Objective: In human heart failure β-adrenergic-mediated protein kinase A (PKA) activity is down-regulated, while protein kinase C (PKC) activity is up-regulated. Methods: Isometric force ...

Cardiovascular Research, van der Velden, Jolanda, Narolska, Nadiya A., Lamberts, Regis R., Boontje, Nicky M., Borbély, Attila, Zaremba, Ruud, Bronzwaer, Jean G.F., Papp, Zoltan, Jaquet, Kornelia, ...

Date : 01/03/2006 Item size : 339099 bytes
Ehjcardiovascrec

[...]the current AHA/ACC HCM guidelines released in 2011 still clearly state that direct therapeutic intervention should be focused on symptom relief, not the diagnosis per se.1 Likewise, the ...

Cardiovascular Research, Tardiff, Jil C., Carrier, Lucie, Bers, Donald M., Poggesi, Corrado, Ferrantini, Cecilia, Coppini, Raffaele, Maier, Lars S., Ashrafian, Houman, Huke, Sabine, van der Velden, ...

Date : 01/04/2015 Item size : 705874 bytes
Ehjcardiovascrec

Abstract The clinical variability in patients with sarcomeric cardiomyopathies is striking: a mutation causes cardiomyopathy in one individual, while the identical mutation is harmless in a family ...

Cardiovascular Research, van der Velden, Jolanda, Ho, Carolyn Y., Tardiff, Jil C., Olivotto, Iacopo, Knollmann, Bjorn C., Carrier, Lucie

Date : 01/04/2015
Ehjcardiovascrec

Abstract Aim Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently been identified to segregate with aggressive forms of familial dilated cardiomyopathy (DCM). Titin ...

Cardiovascular Research, Beqqali, Abdelaziz, Bollen, Ilse A.E., Rasmussen, Torsten B., van den Hoogenhof, Maarten M., van Deutekom, Hanneke W.M., Schafer, Sebastian, Haas, Jan, Meder, Benjamin, ...

Date : 01/10/2016 Item size : 388685 bytes
Ehjcardiovascrec

Methods: Mechanical properties and protein composition of isolated myocytes after Calpain-I exposure (1.25 U/ml; 10 min; 15°C; pCa 5.0) and of ischemic rat hearts following reperfusion were ...

Cardiovascular Research, Papp, Zoltán, van der Velden, Jolanda, Stienen, G.J.M

Date : 01/03/2000 Item size : 318843 bytes
Ehjcardiovascrec

Abstract Aims Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) ...

Cardiovascular Research, Witjas-Paalberends, E. Rosalie, Piroddi, Nicoletta, Stam, Kelly, van Dijk, Sabine J., Oliviera, Vasco Sequeira, Ferrara, Claudia, Scellini, Beatrice, Hazebroek, Mark, ten ...

Date : 01/08/2013
Ehjcardiovascrec

Methods and results By adjusting the parameters of the feedback loop, using a suitably engineered feedback system and recording the developed force and the length of a single rat cardiomyocyte during ...

Cardiovascular Research, Helmes, Michiel, Najafi, Aref, Palmer, Bradley M., Breel, Ernst, Rijnveld, Niek, Iannuzzi, Davide, van der Velden, Jolanda

Date : 01/07/2016 Item size : 277946 bytes
Ehjcardiovascrec

Abstract Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. Recent studies in animal models of heart failure and human failing myocardium converge and ...

Cardiovascular Research, Hamdani, Nazha, Kooij, Viola, van Dijk, Sabine, Merkus, Daphne, Paulus, Walter J., Remedios, Cris dos, Duncker, Dirk J., Stienen, Ger J.M., van der Velden, Jolanda

Date : 01/03/2008