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The HCA aims to describe and define the complete cellular landscape of the human body ( By analogy to the Human Genome Project, the HCA aims to map cells of the ...

Cardiovascular Research, Noseda, Michela, Harding, Sian Elizabeth

Date : 01/10/2018 Item size : 166060 bytes

The aim of this study was to investigate if IL6 trans-signalling, estimated by a ratio between the binary and ternary complexes, associates with the risk of future cardiovascular events (CVE) in a ...

Cardiovascular Research, Ziegler, Louise, Gajulapuri, Ashwini, Frumento, Paolo, Bonomi, Alice, Wallén, Håkan, de Faire, Ulf, Rose-John, Stefan, Gigante, Bruna

Date : 01/01/2019 Item size : 336192 bytes

[...]chronic activation of Epac1 increases the propensity for ventricular arrhythmia by up-regulation of calmodulin protein. Cardiac Epac2, mostly studied in ventricular cardiomyocytes, is located ...

Cardiovascular Research, Pereira, Laetitia

Date : 01/01/2019 Item size : 152632 bytes

Abstract Aims Long noncoding RNAs (lncRNAs) are critical regulators of cardiovascular lineage commitment and heart wall development, but their roles in regulating endogenous cardiac regeneration are ...

Cardiovascular Research, Li, Xinzhong, He, Xiang, Wang, He, Li, Mengsha, Huang, Senlin, Chen, Guojun, Jing, Yuanwen, Wang, Shifei, Chen, Yanmei, Liao, Wangjun, Liao, Yulin, Bin, Jianping

Date : 01/10/2018 Item size : 398751 bytes

Alexander Lukasz, Philipp Kümpers, and their colleagues from the University Hospital Münster, Germany, have studied the mechanisms of breakdown of the endothelial glycocalyx.1 Using confocal ...

Cardiovascular Research, Morawietz, Henning

Date : 01/01/2019 Item size : 154294 bytes

Anti-PCSK9 Mab inhibit the targeted low-density lipoprotein (LDL)-receptor degradation induced by PCSK9 protein and are able to reduce LDL cholesterol (LDL-C) levels on top of conventional ...

Cardiovascular Research, Noto, Davide, Giammanco, Antonina, Barbagallo, Carlo M, Cefalù, Angelo B, Averna, Maurizio R

Date : 01/10/2018 Item size : 454399 bytes

Abstract Aims Generation of reproducible cardiac disease phenotypes in mice is instrumental for investigating mechanisms leading to heart failure (HF). Conclusion Here, we introduce a novel method ...

Cardiovascular Research, Melleby, Arne O, Romaine, Andreas, Aronsen, Jan Magnus, Veras, Ioanni, Zhang, Lili, Sjaastad, Ivar, Lunde, Ida G, Christensen, Geir

Date : 01/10/2018 Item size : 398918 bytes

The goal of revascularization in stable coronary artery disease (SCAD) is to relieve the myocardium from flow-limiting coronary artery disease. Positron emission tomography (PET) using tracers of ...

Cardiovascular Research, Berry, Colin, Bengel, Frank M

Date : 01/01/2019 Item size : 150596 bytes

Introduction Cardiovascular nanomedicine aims to improve diagnosis and treatment of cardiovascular diseases (CVD), which are responsible for the majority of deaths worldwide.1 Regarding diagnostics, ...

Cardiovascular Research, Cicha, Iwona, Chauvierre, Cédric, Texier, Isabelle, Cabella, Claudia, Metselaar, Josbert M, Szebeni, János, Dézsi, László, Alexiou, Christoph, Rouzet, ...

Date : 01/11/2018 Item size : 599259 bytes

The direct effects of CD44 ectodomain on endothelial barrier function were evaluated, which revealed CD44 ectodomain dose-dependently reduced transendothelial electrical resistance (TER) and caused ...

Cardiovascular Research, Yang, Xiaoyuan, Meegan, Jamie E, Jannaway, Melanie, Coleman, Danielle C, Yuan, Sarah Y

Date : 01/11/2018 Item size : 346641 bytes