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Abstract A fundamental structural event in the progression of heart failure due to dilated cardiomyopathy is left ventricular (LV) myocardial remodeling. Using a broad-spectrum pharmacological MMP ...

Cardiovascular Research, Review, Francis G Spinale, Mytsi L Coker, Brian R Bond, James L Zellner

Date : 01/05/2000 Item size : 402448 bytes

Abstract Endothelial production of nitric oxide (nitrogen monoxide, NO) has become a major research area in vascular biology. The aim of this review is to examine the cellular and molecular ...

Cardiovascular Research, Review, Michael T Gewaltig, Georg Kojda

Date : 01/08/2002 Item size : 486616 bytes

Given obvious seasonal-dependent alterations in a number of time-of-day dependent environmental factors (e.g. light/dark cycles), it is not surprising that considerable overlap exists between ...

Cardiovascular Research, Review, Molly S. Bray, Martin E. Young

Date : 15/07/2008 Item size : 405840 bytes

Abstract Objective: Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines and is expressed in various cardiovascular disease states. Methods: Cardiac fibroblasts were isolated from the ...

Cardiovascular Research, Original Article, Darren H Freed, Anna M Borowiec, Tatjana Angelovska, Ian M.C Dixon

Date : 01/11/2003 Item size : 253365 bytes

Aortic stiffness has independent predictive value for total and cardiovascular mortality, coronary morbidity and mortality, and fatal stroke in patients with essential hypertension end-stage renal ...

Cardiovascular Research, Review, Patrick Lacolley, Pascal Challande, Mary Osborne-Pellegrin, Veronique Regnault

Date : 01/03/2009 Item size : 406616 bytes

Abstract Background: We, and others, have previously reported a strong correlation between increased inter-ventricular dispersion of repolarization and the occurrence of fatal arrhythmia in animal ...

Cardiovascular Research, Original Article, Sumeet S Chugh, Stacey Whitesel, Mark Turner, Charles T Roberts, Srinivasa R Nagalla

Date : 01/02/2003 Item size : 273658 bytes

When unfolded protein accumulates secondary to a mild stress, universal protein synthesis is inhibited, but then resumes upon recovery. Nickson et al. found that UPR induced by either tunicamycin, ...

Cardiovascular Research, Editorial, Anne A. Knowlton

Date : 01/01/2007 Item size : 152198 bytes

Several studies, including investigations in humans, have clearly shown an important pathophysiological role of this pathway in the cardiovascular system and in disease states such as hypertension, ...

Cardiovascular Research, Editorial, Stephan L.M. Peters, Martin C. Michel

Date : 01/07/2007 Item size : 162404 bytes

Introduction The endothelium regulates arterial tone by synthesizing and releasing relaxing factors, such as nitric oxide (NO) and prostaglandin I2 (PGI2; prostacyclin), and contracting factors, such ...

Cardiovascular Research, TOPICAL REVIEWS, David C. Ellinsworth, Nilima Shukla, Ingrid Fleming, Jamie Y. Jeremy

Date : 01/04/2014 Item size : 552671 bytes

Abstract The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), ...

Cardiovascular Research, Review, Anne M. Deschamps, Francis G. Spinale

Date : 15/02/2006 Item size : 517696 bytes