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Heart

Rationale The novel anti-diabetic agents, vildagliptin and sitagliptin, reduce blood glucose by augmenting endogenous levels of glucagon-like peptide (GLP-1), a substance which confers ...

Heart, BSCR Spring 2010 Meeting Abstracts, D J Hausenloy, A M Wynne, L Theodorou, M M Mocanu, D M Yellon

Date : 01/09/2010
Heart

Methods/results Inducing mitochondrial fusion in HL-1 cells (a cardiac cell line), using mitochondrial fusion proteins and a pharmacological inhibitor of a mitochondrial fission protein (called ...

Heart, BSCR Spring 2010 Meeting Abstracts, S B Ong, S Arjun, S Y Lim, S M Davidson, D M Yellon, D J Hausenloy

Date : 01/09/2010
Heart

Methodology Hearts from Wistar and Goto Kakizaki rats (GK, a mildly diabetic rat strain) were subjected to 35min coronary artery occlusion in the presence of 10, 20 or 40M A-769662 (an activator of ...

Heart, BSCR Spring 2010 Meeting Abstracts, M Paiva, L M Goncalves, L A Providencia, S M Davidson, M M Mocanu, D M Yellon

Date : 01/09/2010
Heart

A single dose (3mg/kg) of the PHD inhibitor (GSK0360A or PHDi), administered by oral gavage 4h before ex vivo myocardial infarction, reduced myocardial infarct size (percentage of the area at risk) ...

Heart, BSCR Spring 2010 Meeting Abstracts, S-G Ong, S Y Lim, L Theodorou, D H Shukla, P H Maxwell, D M Yellon, D J Hausenloy

Date : 01/09/2010
Heart

PINK1, a kinase localised mainly in mitochondria, can protect neurons against oxidative damage and apoptosis by maintaining mitochondrial structure and function. Hearts isolated from PINK1+/+, ...

Heart, BSCR Spring 2010 Meeting Abstracts, H Siddall, R Sands, S M Davidson, D J Hausenloy, M M Mocanu, D M Yellon

Date : 01/09/2010
Heart

In other systems, nicotinic acid adenine nucleotide phosphate (NAADP) acts as a second messenger to stimulate Ca2+ release from acidic intracellular Ca2+ stores, which in turn triggers Ca2+ release ...

Heart, BSCR Spring 2010 Meeting Abstracts, N S Tan, S M Davidson, D M Yellon

Date : 01/09/2010
Heart

A Myat1, S R Redwood1, B J Gersh2, D M Yellon3, M S Marber1 1Cardiovascular Division, King's College London BHF Centre of Research Excellence, The Rayne Institute, St Thomas Hospital, London, UK ...

Heart, Education in Heart, A Myat, S R Redwood, B J Gersh, D M Yellon, M S Marber

Date : 01/10/2014
Heart

Mice deficient in Akt1 or Akt2 were subjected to in vivo regional myocardial ischaemia for 30min followed by reperfusion for 2h with or without a prior IPC stimulus, comprising 5min of ischaemia ...

Heart, BSCR Spring 2010 Meeting Abstracts, S P Kunuthur, D J Hausenloy, D M Yellon

Date : 01/09/2010
Heart

BAS/BSCR45 The mitochondrial permeability transition pore as a target for cardioprotection in ventricular cardiomyocytes harvested from patients with obstructive hypertrophic cardiomyopathy The ...

Heart, BSCR Spring 2010 Meeting Abstracts, P S C Rees, S M Davidson, S E Harding, P M Elliot, D M Yellon, D J Hausenloy

Date : 01/09/2010